We don’t know for sure as the Bible does not say. However, there is no reason to think that Adam and Eve did not have a normal relationship as husband and wife while in the garden of Eden. They were told to “be fruitful and multiply” (Genesis 1:28) which suggests that they engaged in sexual relations from the beginning.
No children are described until after they left the garden of Eden. However, the curse on Eve included the words “I will surely multiply your pain in childbearing” (Gen 3:16) which implies that she may have had children earlier.